Retinal and Choroidal Blood Perfusion in Patients with Biett
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A Study was conducted to compare the changes of chorioretinal blood perfusion between Bietti crystalline dystrophy (BCD) and typical retinitis pigmentosa (RP) and perform a staging and a longitudinal analysis of chorioretinal perfusion in BCD.

The study included 28 BCD patients, 28 traditional RP patients, and 28 healthy volunteers. Optical coherence tomography was used to measure macular structural parameters and subfoveal choroidal thickness. Optical coherence tomography angiography was used to measure retinal vessel and perfusion densities. Indocyanine-green angiography was used to determine choroidal blood perfusion. The BCD group's results were similar to those of the RP and control groups, and then BCD was staged and studied longitudinally.

Results:
--Macular structural and perfusion parameters were decreased less in the BCD group than those in the RP group.

--Subfoveal choroidal thickness was significantly thinner in the BCD group, with a remarkable choroidal perfusion deficit using indocyanine-green angiography.

--The staging analysis revealed damage of both retinal and choroidal perfusion in BCD, however, the longitudinal analysis showed the impairment of choroidal perfusion outweighed retinal.

Conclusively, both retinal and choroidal blood perfusion are impaired in BCD, but choroidal perfusion deficit caused by CYP4V2 mutations may play a more vital pathologic role.

Source: https://journals.lww.com/retinajournal/Abstract/9000/Retinal_and_Choroidal_Blood_Perfusion_in_Patients.95512.aspx
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