Retinal oxygen saturation is associated with HbA1c diabetes
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A study was conducted to find an association of retinal oxygen saturation (SatO2) with acid–base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemoglobin A1c (HbA1c), and other conditions.

41 adults with type 1 or type 2 diabetes mellitus, age 48.6 ± 13.5 years, diabetes duration 9 years, BMI 29.4 ± 6.3 kg/m2, and HbA1c 52 ± 12.7 mmol/mol completed the study. The 4 day study comprised two visits (Day l, Day 4) including 72 hr of continuous glucose monitoring (CGM) by iPro®2 Professional CGM. Retinal oximeter Oxymap T1 was used to assess SatO2.

Results:
--Wilcoxon signed rank test showed no SatO2 difference between eyes and visits.

--Spearman's correlation analysis revealed a significant correlation between arterial SatO2 and PG variability in type 2 diabetes mellitus, a positive correlation of venous SatO2 with HbA1c and with finger pulse oximetry.

--However, no correlation of SatO2 with ABB, carboxyhaemoglobin, current PG, mean PG over the 72 hr, age, diabetes duration, BMI, lipoproteinaemia, body temperature, systolic and diastolic blood pressure, heart rate, central retinal thickness and retinal nerve fibre layer thickness was found.

The connection between venous SatO2 and long-term diabetes control, ABB, and other conditions was confirmed in this research. A research challenge is the increased SatO2 and uncertain effect of PG variability on retinal SatO2.

Source: https://onlinelibrary.wiley.com/doi/10.1111/aos.14853?af=R
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