Right and Left Ventricular Function in Extremely Premature N
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A Study was conducted to identify the measures of biventricular function and surrogates of pulmonary vascular resistance that can be expected in relatively stable extremely premature neonates, and evaluate maturational changes in myocardial performance in this patient population.

This was a prospective observational study. Clinically stable extremely preterm newborns were divided into 3 cohorts based on gestational age: cohort 1 (240/7 – 256/7 weeks), cohort 2 (260/7 – 276/7 weeks), and cohort 3 (280/7 – 296/7 weeks). Serial echocardiograms were obtained on day of life (DOL) 3-5, 7-10, and just prior to discharge.

Results:
--46 subjects met the criteria aimed at capturing only the most clinically healthy and stable newborns less than 296/7 weeks gestational age.
--Myocardial performance was reliably assessed by echocardiography with high inter-reader correlation.
--Normative values were identified for right ventricular function, left ventricular function, and surrogates of pulmonary vascular resistance.

Finally, as compared to healthy full-term newborns, biventricular systolic output is substantially different in clinically stable extremely premature neonates. At birth, all of the participants had low biventricular compliance, which increased as they grew older. At term corrected age and/or discharge, extreme prematurity does not seem to have an adverse effect on myocardial functional maturation.

Source: https://www.jpeds.com/article/S0022-3476(21)00437-6/fulltext?rss=yes
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