Risk factors for enterocolitis in patients with Hirschsprung
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Hirschsprung-associated enterocolitis (HAEC) accounts for substantial morbidity and mortality in patients with Hirschsprung disease (HD). The study states that Patient and clinical characteristics were not associated with a higher risk of developing HAEC.

The aim of this study was to identify the incidence of pre- and postoperative HAEC in our consecutive cohort and to identify patient and clinical characteristics that are associated with developing postoperative HAEC and HAEC-free intervals.

A retrospective cohort study was performed with all 146 HD patients treated between 2000 and 2017. HAEC was defined as the presence of clinical signs of bowel inflammation, that required treatment with intravenous antibiotics and admittance to the hospital for at least two days. To identify risk factors for HAEC, patients with and without a history of postoperative HAEC were compared. Kaplan-Meier and Cox regression were used to assess HAEC-free intervals before and after surgery.

--Out of 146 patients, 12 patients had pre-operative HAEC and 31 patients had postoperative HAEC.

--The median preoperative HAEC free interval was 112 days.

--Length of hospital stay due to readmissions was longer for patients with a history of postoperative HAEC compared to patients without a history of postoperative HAEC.

--The median postoperative HAEC free interval was 226 days. Of the patients who had postoperative HAEC, 66% had their first episode within the first year after surgery, and that the incidence of HAEC declined over follow-up.

In particular, HAEC incidence was relatively low in our population. No patient or clinical characteristics were associated with the risk of postoperative HAEC.

Journal of Pediatric Surgery
Source: https://doi.org/10.1016/j.jpedsurg.2021.04.020
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