Risk of dementia was decreased in Open-angle Glaucoma patien
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The risk of developing dementia or Alzheimer’s disease was decreased in Open-angle Glaucoma patients compared with the general population. Open-angle Glaucoma with onset at a later age may present as a different etiopathogenetic entity compared to onset at a younger age, representing the optic nerve findings of generalized neurodegenerative processes.

In this population-based study of 509 open-angle glaucoma patients over a 36-year period. The objective of this study was to determine the incidence of dementia and Alzheimer’s disease among patients with open-angle glaucoma.

Of the 509 patients included, 300 (58.9%) were female, the median age was 67.5 years, and 278 patients (54.6%) had primary OAG. Other subgroups were pseudoexfoliation in 15.1%, treated ocular hypertension in 14.1%, normal-tension glaucoma in 10.6%, and pigmentary glaucoma in 5.5% of the patients. Respectively, 118 and 99 patients developed dementia and Alzheimer’s disease. The 10-year cumulative probability of developing dementia and Alzheimer’s disease was 12.0% and 9.9%, with a 95% confidence interval of 9.3-15.3% and 7.5-13%, respectively. The observed 10-year incidence of dementia and Alzheimer’s disease were significantly lower than the expected population incidence. Older age at diagnosis of glaucoma was a strong predictor for the development of dementia by multivariate analysis.

Source:https://pubmed.ncbi.nlm.nih.gov/33394844/
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