Risk of fetal loss following amniocentesis or chorionic vill
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A study was conducted to assess the rate of fetal loss following amniocentesis or chorionic villus sampling (CVS) in twin pregnancy.

Sixteen studies (3419 twin pregnancies undergoing and 2517 not undergoing an invasive procedure) were included. Head-to-head meta-analyses comparing directly twin pregnancies undergoing and those not undergoing amniocentesis showed a higher risk for overall fetal loss in those undergoing amniocentesis, while there was no difference in the risk of either fetal loss before 24-weeks of gestation or fetal loss within 4-weeks after the procedure. Overall, the pooled rate of fetal loss was 2.4% in twin pregnancies undergoing amniocentesis compared with 2.4% in those not undergoing amniocentesis. Head-to-head meta-analyses directly comparing twin pregnancies undergoing and those not undergoing CVS showed no significant difference in either overall fetal loss or fetal loss before 24-weeks of gestation. Overall, the pooled rate of fetal loss was 2.0% in twin pregnancies undergoing CVS compared with 1.8% in those not undergoing CVS.

The risk of fetal loss following amniocentesis and CVS in twins is lower than reported previously and the rate of fetal loss before 24-weeks of gestation, or within 4-weeks after the procedure, did not differ from the background risk in twin pregnancy not undergoing invasive prenatal testing. These data can guide prenatal counseling for twin pregnancies undergoing invasive procedures.

Source:https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.22143
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