Risks of corneal surface damage in aqueous deficient dry eye
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A Study was conducted to investigate the epidemiological characteristics and risk of corneal surface damage in patients with aqueous deficient dry eye disease (DED) in Taiwan.

Researchers used claims data of patients with DED, defined according to diagnosis, drug codes, and clinical follow-up. A comparison cohort without DED was selected through propensity score matching. The main outcome measures were corneal surface damage, including corneal erosion, corneal ulcers, or corneal scars.

Results:
--Patients with DED had a significantly higher rate of corneal surface damage (HR: 2.70), especially higher in patients less than 18 years (HR 6.66) than in older patients and in women (HR 2.98) than in men (HR 2.22) compared to those in the non-DED cohort.

--DED with diabetes mellitus, rheumatic arthritis, or systemic lupus erythematosus was positively associated with corneal surface damage.

--The overall prevalence of DED was 7.85%, higher among women (10.49%) than men (4.92%), increased with age (0.53%, 3.94%, 10.08%, and 20.72% for ages of less than 18, 18-39, 40-64, and more than 65 years, respectively). The prevalence increased gradually during the study period.

Finally, in aqueous deficient DED, the younger age group (less than 18 years) had the highest risk of corneal surface injury. Female sex, diabetes, and autoimmune disorders were also predisposing factors. Specific treatment is needed for patients with DED who have these risk factors in order to enhance clinical care.

Source: https://www.ajo.com/article/S0002-9394(21)00126-4/fulltext?rss=yes
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