Rivaroxaban and aspirin used in prevention of venous thrombo
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A Study was conducted to evaluate the efficacy and safety of rivaroxaban versus aspirin in prevention of venous thromboembolism (VTE) following total hip (THA) or knee arthroplasty (TKA) or hip fracture surgery.

Results:
--In total, 7 studies were retrieved which contained 5133 patients. Among these patients, 2605 patients (50.8%) received rivaroxaban, whereas 2528 patients (49.2%) received aspirin.

--There were no statistical difference between aspirin and rivaroxaban for reducing VTE (RR = 0.75), major bleeding (RR = 0.94), and all-cause mortality (RR = 0.88) between the two groups.

--Compared with aspirin, rivaroxaban significantly increased nonmajor bleeding (RR = 1.29).

In particular, there was no significant difference between aspirin and rivaroxaban in prevention of venous thromboembolism following total joint arthroplasty or hip fracture surgery. Aspirin may be an effective, safe, convenient, and cheap alternative for prevention of VTE.

Source: https://journals.lww.com/jaaos/Abstract/2021/02150/Spinopelvic_Dissociation__A_Systematic_Review_and.12.aspx
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