Role Of Probiotics As Therapeutic Strategy To Prevent Progre
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Gastrointestinal disorders are frequent in COVID-19 and SARS-CoV-2 has been hypothesized to impact on host microbial flora and gut inflammation, infecting intestinal epithelial cells. This study aimed to evaluate the possible role of a specific oral bacteriotherapy as complementary therapeutic strategy to avoid the progression of COVID-19.

A study of 70 patients positive for COVID-19 was conducted who had fever, required non-invasive oxygen therapy and presented a CT lung involvement on imaging more than 50%. Forty-two patients received hydroxychloroquine, antibiotics, and tocilizumab, alone or in combination. A second group of 28 subjects received the same therapy added with oral bacteriotherapy, using a multistrain formulation.

The formulation administered in this study contained predominant genus Lactobacillus strains: consisting of Streptococcus thermophilus, L.acidophilus, L. helveticus, L. paracasei, L. plantarum, L. brevis, B. lactis, B. lactis. The oral probiotic treatment involved the use of 2,400 billion bacteria per day, administered in three equal doses.

Results:
The two cohorts of patients were comparable for age, sex, laboratory values, concomitant pathologies, and the modality of oxygen support. Within 72 h, nearly all patients treated with bacteriotherapy showed remission of diarrhea and other symptoms as compared to less than half of the not supplemented group.

The estimated risk of developing respiratory failure was eight-fold lower in patients receiving oral bacteriotherapy. Both the prevalence of patients transferred to ICU and mortality were higher among the patients not treated with oral bacteriotherapy.

Conclusion:
A specific bacterial formulation showed a significant ameliorating impact on the clinical conditions of patients positive for SARS-CoV-2 infection. These results also stress the importance of the gut-lung axis in controlling the COVID-19 disease.

Source:
https://www.frontiersin.org/articles/10.3389/fmed.2020.00389/full
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