Role of PRP injection in delayed union and nonunion of long
The evidence for PRP osteogenic potential has been suggested by several in vitro studies, i.e. PRP addition in culture medium promoted the proliferation and differentiation of human mesenchymal stem cells (MSCs) and the effect of PRP on osteogenic differentiation was also seen on human adipose-derived stem cell (ADSC). A study was conducted to study the role of PRP in accelerating bone healing potential at the fracture site in cases of delayed union or non union of long bones.

20 patients with delayed/non union of long bone fractures were treated with PRP injection. The patients were assessed for callus formation over radiological examination. In study 65 percent of the patients benefitted from PRP therapy and showed good callus formation and 35 percent did not benefit from the treatment and required further operative intervention.

The use of PRP in treatment of non union and delayed union of long bone fractures has shown good results with no complications, it is a promising new modality which needs prospective, randomised, placebo-controlled, multicentric-studies with a much larger sample size to clarify the results and better understanding of the effects of PRP in fracture healing.