Role of Pneumatic Vitreolysis with C3F8 for Vitreomacular Tr
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A Study was conducted to evaluate the pneumatic vitreolysis (PVL) in eyes with vitreomacular traction (VMT) with and without full-thickness macular hole (FTMH).

Adults with central VMT with a vitreomacular adhesion of less than 3000 microm took part in the study. Visual acuity (VA) ranged from 20/32 to 20/400 in AG. FTMH (less than 250 microm at the narrowest point) and VA of 20/25 to 20/400 were found in AH eyes.

Results:
--46 participants were enrolled in AG and 35 eligible participants were enrolled in AH.

--Higher than expected rates of retinal detachments and tears resulted in early termination of both protocols. Combining studies, 7 of 59 eyes that received PVL developed rhegmatogenous retinal detachment (6) or retinal tear (1).

--At 24 weeks in AG, 18 of 23 eyes in the PVL group versus 2 of 22 eyes in the sham group had central VMT release without rescue vitrectomy.

--The mean change in VA letter score from baseline at 24 weeks in AG was 6.7 in the PVL group and 6.1 in the sham group.

--In AH,10 of 35 eyes had FTMH closure without rescue vitrectomy at 8 weeks. The mean change in VA from baseline at 8 weeks in AH was -1.5 letters.

Finally, pneumatic vitreolysis caused hyaloid release in most eyes with vitreomacular traction. In around one-third of eyes with full-thickness macular holes, pneumatic vitreolysis resulted in hole closure.

Source: https://www.aaojournal.org/article/S0161-6420(21)00353-5/fulltext?rss=yes
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