Role of Preventive bundle approach in ventilator-associated
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The researchers anticipated that by combining evidence-based therapies into a bundle, the incidence of ventilator-associated pneumonia (VAP) in the neonatal critical care unit may be greatly reduced.

A prospective observational cohort study including neonates undergoing mechanical ventilation more than 48?h was conducted. VAP rate and endotracheal intubation ratio were compared before (pre-period) and after (post-period) applying VAP prevention bundle strategies.

Result:
--174 neonates were included in pre-period (30 months) and 106 in post-period (17 months).

--Demographic characteristics were comparable and device use ratios were similar.

--28 VAP episodes were diagnosed, 25 in the first period and 3 after the implementation of prevention bundle. This represents a reduction in the incidence rate from 11.79 to 1.93 episodes/1000 ventilator days.

Finally, adopting a bundle approach to administer an educational evidence-based program to prevent VAP resulted in a statistically significant reduction in its incidence density.

Source: https://www.nature.com/articles/s41372-021-01086-7
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