Role of Renal Biomarkers for early Kidney Injury in Immunogl
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A Study was conducted with an aim to determine whether urine Kidney Injury Molecule 1 (KIM 1) and Neutrophil Gelatinase Associated Lipocalin (NGAL) can be used as early noninvasive biomarkers of kidney injury in Immunoglobulin A vasculitis. Patients who were diagnosed with Immunoglobulin A vasculitis were included in the study. Urine samples were collected for determination of urine KIM-1 and NGAL levels. The control group was comprised of age-matched healthy children.

Results:
61 patients who were diagnosed with Immunoglobulin A vasculitis were included in the study.
-37.7% of these patients were determined to have renal involvement.
-Median KIM-1 was found to be statistically significantly higher in the patient group (69.59 pg/ml) compared to the control group (40.84 pg/ml).
-Median NGAL was determined to be statistically significantly higher in the patient group (59.87 ng/ml) compared to the control group (44.87 ng/ml).
-23.6% of the patients without renal involvement at admission were found to develop renal involvement within following 6 months.
-When median KIM-1 and NGAL at admission of these patients were compared with the control group, they were determined to be statistically significantly higher.

The fact that our patients with late-term nephropathy had no hematuria and/or proteinuria and that KIM-1and NGAL levels, however, were determined to be high indicates that these biomarkers might be potentially reliable, noninvasive and early determinants of kidney injury.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.14600?af=R
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