Role of Trimetazidine in CAD : The heart is capable of using
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Role of Trimetazidine in CAD : The heart is capable of using fatty acids and glucose as its main sources of energy, with their balance depending on many physiological and pathological situations. In the presence of ischemia, there is a switch to oxidation of fatty acids, which has deleterious effects on the function of the heart. Trimetazidine reduces fatty acid oxidation and increases glucose oxidation, which tends to normalize the metabolism and function of the heart in ischemia and diabetes. It has been shown that trimetazidine reduces angina andischemiainpatientswith stablecoronaryartery disease –aneffect that has also been observed in patients with coronary artery disease who have diabetes mellitus.
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