Role of lipid profile in early second trimester for predicti
The study suggests that lipid profile in the early second trimester can be a helpful measure for the prediction of pre-eclampsia.

The aim of the study was to determine the association of abnormal lipid profiles in the early second trimester (14 to 20 weeks) with the development of pre-eclampsia.

A prospective observational study included 260 women between 14-20 weeks of pregnancy. Serum lipid profile analysis was performed at the time of enrolment and cohort was followed up for occurrence of pre-eclampsia till 48 hours after delivery. Outcomes measured were differences in mean lipid levels in the study (abnormal lipid profile) and control group (normal lipid profile) and accuracy of an abnormal lipid profile to predict pre-eclampsia.

- The incidence of pre-eclampsia in the study was 11.13%. The mean serum total cholesterol was significantly higher in the preeclampsia group.

- The difference in mean triglyceride, HDL, VLDL, and LDL levels between the two groups was not significant.

- Total cholesterol has 44.83% sensitivity, 84.85% specificity, 27.08% PPV, 92.45% NPV with diagnostic accuracy of 80.38% in predicting pre-eclampsia.

- While VLDL has a maximum sensitivity of 68.97% while HDL has maximum specificity of 86.15% in predicting pre-eclampsia.

In particular, abnormal total cholesterol levels have diagnostic accuracy of 80.38% to predict pre-eclampsia and abnormal lipid profile in the early second trimester is a simple, non-invasive and economical test for the prediction of pre-eclampsia.