Role of oncostatin M in the pathogenesis of vernal keratocon
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Vernal keratoconjunctivitis is a severe and recurrent allergic conjunctivitis, the mechanism of which is not well understood. In this study, researchers investigated the role of oncostatin M in the pathogenesis of Vernal keratoconjunctivitis, with a focus on tissue remodeling. The results suggest that oncostatin M is one of the key molecules involved in the remodeling of giant papillae in Vernal keratoconjunctivitis

The oncostatin M concentrations in tear fluid samples obtained from Vernal keratoconjunctivitis patients and healthy controls were measured using ELISA, and the expression of oncostatin M mRNA and protein in giant papillae resected from Vernal keratoconjunctivitis patients was investigated using RT-PCR and immunohistochemistry, respectively. In cultured human conjunctival epithelial cells, expression of oncostatin M receptor was detected using immunocytochemical and FACS analyses.

The oncostatin M concentration was higher in the tear fluid of Vernal keratoconjunctivitis patients than in that of the healthy controls, and strong expression of oncostatin M mRNA was found in the giant papillae. Researchers also detected T cells expressing oncostatin M in the giant papillae. In addition, human conjunctival epithelial cells showed surface expression of oncostatin M receptor. Recombinant human oncostatin M strongly activated both STAT1 and STAT3 in human conjunctival epithelial cells and induced.

Source:https://pubmed.ncbi.nlm.nih.gov/33403505/
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