Role of salivary biomarkers for detection of systemic diseas
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According to researchers, analysis of inflammatory biomarkers in saliva could offer an attractive opportunity for the diagnosis of different systemic conditions specifically in epidemiologic surveys.

The aim of this study by the Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology was to investigate if certain salivary biomarkers could be used for detection of common systemic diseases.

A randomly selected sample of 1000 adults living in Belgaum, India, was invited to participate in a clinical study of oral health. A total of 451 individuals were enrolled in this investigation. All participants were asked to fill out a questionnaire. Their histories were taken, clinical examinations were performed, and stimulated saliva samples were collected. Salivary concentrations of interleukin (IL)-1b, IL-6, IL-8, tumor necrosis factor-α, lysozyme, matrix metalloproteinase (MMP)-8, and tissue inhibitor of metalloproteinase (TIMP)-1 were determined using enzyme-linked immunosorbent assay.

The outcomes were;
--Salivary IL-8 concentration was found to be twice as high in patients who had tumor diseases.

--In addition, IL-8 levels were also elevated in patients with bowel disease.

--MMP-8 levels were elevated in the saliva of patients after cardiac surgery or in those with diabetes and muscle and joint diseases.

--The levels of IL-1b, IL-8, and MMP-8, as well as the MMP-8/TIMP-1 ratio, were higher in patients with muscle and joint diseases.

In conclusion, biomarkers in saliva have the potential to be used for screening purposes in epidemiologic studies.