SMART researchers find new way to make bacteria more sensiti
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In most bacteria studied, the production of endogenous H2S has been speculated as a universal defence mechanism in bacteria against antibiotics.

• Researchers from Singapore-MIT Alliance for Research and Technology (SMART) tested that theory by adding H2S releasing compounds to Acinetobacter baumannii – a pathogenic bacteria that does not produce H2S on its own.

• They found that rather than causing antibiotic tolerance, exogenous H2S sensitised the A. baumannii to multiple antibiotic classes.

• It was even able to reverse acquired resistance in A. baumannii to gentamicin, a very common antibiotic used to treat several types of infections.

• The results of their study are discussed in a paper titled “Hydrogen sulfide sensitizes Acinetobacter baumannii to killing by antibiotics” published in the journal Frontiers in Microbiology.

• Principal Investigator at SMART said, “this is a very exciting discovery because we are the first to show that H2S can, in fact, improve sensitivity to antibiotics and even reverse antibiotic resistance in bacteria that do not naturally produce the agent.”

• While the study focused on the effects of exogenous H2S on A. baumannii, the scientists believe the results will be mimicked in all bacteria that do not naturally produce H2S.

Source: https://www.frontiersin.org/articles/10.3389/fmicb.2020.01875/full
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