Safe, effective DNA-based Zika vaccine developed
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A study published in the New England Journal of Medicine introduces GLS-5700, a synthetic DNA vaccine which can produce an immune response against a specific Zika virus antigen with minimal adverse effects. These DNA vaccines can be designed and manufactured rapidly, appear to be highly predictable for the generation of immunity in humans and have significant conceptual safety advantages.

In the human trial, two groups of 20 participants received two different doses of the vaccine candidate intradermally at zero, four, and 12 weeks. Each dosage was followed by Cellectra delivery at the site, which generates small, directional electric currents into the skin to facilitate optimal vaccine uptake, production of the intended antigen, and immune responses. Two weeks after the final dose 100% of study participants developed Zika-specific antibodies and 80% developed significant neutralizing antibodies against the virus. The serum collected from the participants was able to protect immunocompromised mice from developing the disease after infection with Zika virus, indicating that the vaccine-induced antibodies can prevent infection in vivo.

With the success of this study, researchers believe that they are one step closer to hopefully finding a way to prevent Zika infection...

http://indiatoday.intoday.in/story/safe-effective-dna-based-zika-vaccine-developed/1/1062069.html
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