Safety & Efficacy of Endovascular intervention for refractor
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CVST (cerebral venous sinus thrombosis) is a rare but potentially fatal condition in children, and the best treatment is endovascular intervention, according to the findings.

The Stroke Thrombectomy and Aneurysm Registry (STAR) was queried for patient less/equal to 18 years of age undergoing endovascular treatment for CVST in the past 10 years. Clinical charts and radiographic data were retrospectively reviewed. Modified Rankin Score (mRS) at 90 days post-procedure was determined as the primary outcome.

Results:
--A total of 7 patients across 5 pediatric centers ranging from 7 to 16 years of age were identified with a mean follow up of 28 months.

--All had underlying conditions predisposing to CVST.

--Endovascular intervention was undertaken due to neurological deterioration despite systemic anticoagulation; venous infarct was evident pre-operatively in 6 of 7 patients.

--Mechanical venous thrombectomy was attempted in all individuals, and intrasinus thrombolytic therapy was also performed in three cases.

--6 patients had favorable outcome with mRS 0 or 1 at 90-days post-procedure; 1 remained neurologically devastated.

Finally, in serious cases of CVST in Children who have failed frontline therapy, endovascular care by an experienced interventionalist can be Safe and Effective. Many who have progressed radiographically or clinically despite anticoagulation may be candidates for endovascular intervention.

Source: https://www.sciencedirect.com/science/article/abs/pii/S0887899421000989?dgcid=rss_sd_all
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