Safety and Indicative Effectiveness of Porcine Corneal Lenti
This study aimed to evaluate the safety and feasibility of implanting decellularized porcine corneal lenticules in a femtosecond laser-assisted pocket for patients with advanced keratoconus and post-Lasik ectasia.

This is a retrospective clinical study of implanting a porcine corneal lenticular implant in 7 eyes: 6 with advanced keratoconus and clear cornea and 1 with advanced post-Lasik ectasia with a follow-up for 12 months.

The lenticules are extracted from porcine tissue, subjected to a decellularization process, intensely cross-linked, sterilized and packed. They are 7 mm in diameter with at 100– 120-micron thickness. The femtosecond laser was used to create an intra-stromal pocket, and then the lenticules were implanted inside the pocket followed by corneal cross-linking 3 months later for 6 out of 7 eyes.

--5 patients had keratoconus (6 eyes) and 1 patient (one eye) had post-Lasik ectasia.

--Visual acuity improved in all patients except for one case at 6 and 12 months and this was statistically significant.

--At one-year follow-up, the mean central corneal thickness increased from 389.43 ± 45.41 to 429.33± 63.20 microm, the maximum keratometry decreased from 64.8 ± 5.11 to 62.82± 6.16 D, the mean corneal resistance factor (CRT) increased from 5.67 to 8.42, and the total higher-order aberrations decreased from 1.80 to 1.16.

--Both changes in the CCT and CRF were statistically significant. One eye had wrinkles and opacified graft, and it was exchanged 3 months postoperatively.

Finally, implantation of porcine corneal lenticules is immunologically safe and well tolerated in patients with advanced keratoconus and post-Lasik ectasia, suggesting that it may be a viable option to keratoplasty.