Safety and efficacy of a novel barrier film to prevent intra
The study suggests that degradable polymer film is effective in preventing intrauterine adhesion formation after hysteroscopic myomectomy.

The objective was to evaluate the safety and potential efficacy of a novel degradable polymer film (DPF), designed to act as a 7-day barrier to prevent intrauterine adhesions (IUAs), post hysteroscopic myomectomy.

Women ?40 years with no plans to conceive who qualified for hysteroscopic myomectomy and had a sounded length of the uterine cavity (fundus to exocervix) ranging between 6 – 9 cm, were considered eligible for the study. The DPF was inserted following hysteroscopic transcervical myoma resection.

The chosen safety outcome measures were uterine perforation or cervical trauma at the time of the DPF insertion and unexpected fever, pain, or bleeding beyond 48 hours and up to 30 days post-insertion, while the outcome measure for efficacy was the absence of adhesions on second look hysteroscopy. A total of 23 women participated in the study.

- There were no incidents of uterine perforation or cervical trauma at the time of the DPF insertion.

- There were no reported side effects attributable to the film. On second look hysteroscopy, 20 of 23 women had no intrauterine adhesions.

In particular, the degradable polymer film is a novel, easy to apply, and acceptable device for intrauterine adhesion prevention with very promising initial safety and efficacy data.

The Journal of Minimally Invasive Gynecology