Safety of topical ophthalmic antibiotics in pregnant women w
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A Study was conducted to investigate the association between exposure to topical ophthalmic antibiotics during pregnancy and adverse neonatal outcomes which inferred that outcomes were not severe.

Researchers identified pregnant women with hordeola, chalazia, blepharitis, or bacterial conjunctivitis. From the eligible women, women who were dispensed no topical antibiotics during the first trimester (non-antibiotic group), women who were dispensed topical fluoroquinolones alone at least once (fluoroquinolone alone group), and women who were dispensed any single type of antibiotic (single-antibiotic group) were extracted.

The frequency of congenital anomalies (CA), preterm birth (PB), low birth weight (LBW), and the composite outcome of these three between the fluoroquinolone and non-antibiotic groups and between the single-antibiotic and non-antibiotic groups, using propensity score adjustment were compared.

Results:
--A total of 891 eligible women were identified. In the fluoroquinolone (n=409) and non-antibiotic (n=309) groups, CA occurred in 6.8% and 6.8%, PB in 2.4% and 3.2%, LBW in 2.9% and 3.2%, and the composite outcome in 10.5% and 11.3%, respectively.

--Analysis using propensity score adjustment showed no significant difference between the groups in the frequency of CA (adjusted odds ratio, 1.15), PB (0.80), LBW (1.08), or the composite outcome (1.12).

--Comparison of the single-antibiotic and non-antibiotic groups showed similar results.

During the first trimester, topical ocular medications for hordeola, chalazia, blepharitis, or bacterial conjunctivitis were not linked to an increased risk of bad newborn outcomes.

Source: https://www.nature.com/articles/s41433-021-01586-y?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+eye/rss/current+(Eye+-+Issue)
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