Sarcoid- like Phenomenon - ustekinumab induced granulomatous
Monoclonal antibody therapies have been frequently used in recent years in the treatment of chronic inflammatory disorders due to their distinctive immunosuppressive and selective properties. Ustekinumab is a human monoclonal antibody (mAb) designed to block interleukin (IL)-12 and IL-23 from binding to their p40 Beta subunit receptors on the surface of T and natural killer (NK) cells.

A 50-year-old Causcasian man with a known history of refractory psoriasis on treatment with ustekinumab presented with a complaint of significant weight loss and shortness of breath. Physical examination was unremarkable and blood cultures were negative. A chest computed tomography (CT) scan was performed and revealed a large right lung mass with adjacent nodularity in addition to right-sided pleural effusion, and possibility of primary lung malignancy was raised.

Therapeutic thoracocentesis was done; fluid cytology and analysis were negative for malignancy, acid-fast bacilli, or fungal infections.

Source: Journal of Medical Case Reports

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