Scientists Discover Drug That Can Stop Tumours From Growing
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Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers who claimed to have found a drug that can reduce inflammation and the resultant tumour expansion. Scientists detailed their work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumour growth and progression.

By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumour expansion. Specifically, NLRP3 promotes inflammation by inducing the maturation and release of interleukin-1-beta, a cytokine that causes inflammation as part of the normal immune response to infection. In cancer, however, inflammation can cause tumours to grow and spread.

NLRP3 is a member of a larger family that is involved in sensing danger signals. It is a receptor that surveils the intercellular compartment of a cell, looking for dangerous molecules or pathogens. When NLRP3 recognizes these signals, it leads to the activation of caspase-1, causing an intense inflammatory response.

The oral NLRP3 inhibitor used in their study (Dapansutrile) has already shown to be effective in clinical trials to treat gout and heart disease, and it is currently being tested in COVID-19 as well. The CU cancer researchers are now trying to find out if this NLRP3 inhibitor can be successfully used in melanoma patients who are resistant to checkpoint inhibitors.

With the hypothesis that an NLRP3 inhibitor is one of those therapies, researchers are studying the drug's effects on melanoma, as well as breast cancer and pancreatic cancer. In addition to improving the immune response, the NLRP3 inhibitor can also help reduce the side effects of checkpoint inhibitors. The researcher says this research can make a big difference for melanoma patients who don't respond to checkpoint inhibitors alone.

Source:
https://www.aninews.in/news/science/scientists-discover-drug-that-can-stop-tumours-from-growing20210408221943/
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