Scientists decode how lungs are damaged in severe COVID-19 u
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Using a novel technique which enables high-resolution imaging of damaged lung tissues, scientists have found the changes caused by severe COVID-19 in the structure of the organ's blood vessels and air sacs.

In the study, published in the journal eLife, the scientists developed a new X-ray technique which enables high resolution and three-dimensional imaging of lung tissues infected with the novel coronavirus SARS-CoV-2.

Using the new method, the researchers observed significant changes in the blood vessels, inflammation, and a deposition of proteins and dead cells on the walls of the lungs' tiny air sacs called alveoli.

They said these changes make a gas exchange by the organ either difficult or impossible.

According to the scientists, the new imaging approach allows these changes to be visualised for the first time in larger tissue volumes, without cutting and staining, or damaging the tissue.

Due to the three-dimensional reconstruction of the lung tissues, the researchers said the data could also be used to simulate gas exchange in the organ.

"Based on this first proof-of-concept study, we propose multi-scale phase-contrast X-ray tomography as a tool to unravel the pathophysiology of COVID-19," the researchers wrote in the study.

The scientists believe the technique will support the development of treatment methods, and medicines to prevent or alleviate severe lung damage in COVID-19, or to promote recovery.

Source: https://www.tribuneindia.com/news/health/scientists-decode-how-lungs-are-damaged-in-severe-covid-19-using-novel-imaging-technique-130295
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