Second Shot Of COVID-19 Vaccine May Not Be Necessary In Prev
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A single shot of one of the currently authorized COVID-19 vaccines may be sufficient to provide immunity, a study finds. Researchers studied 109 individuals with and without previous SARS-CoV-2 immunity. Those who had the vaccine developed antibodies at a rate 10 to 20 times higher than those who were uninfected.

The second dose of the vaccine increased antibodies at more than a tenfold rate after the first dose. These findings suggest that a single dose of vaccine elicits a very rapid immune response. The team also investigated systemic reactions after the first dose of vaccine in the second group of 231 individuals, 83 of whom had tested positive for COVID-19, and 148 who had not.

While the vaccines were generally well-tolerated, injection site symptoms—including pain, swelling, and reddening of the skin—were found in both sub-groups. In recipients with pre-existing immunity, however, side effects occurred with a significantly higher frequency, including fatigue, headache, chills, fever, and muscle or joint pain.

The reason for the stronger response in both groups is likely due to the fact the body has already been primed. If the infection history of an individual is unknown, using a serological assay. If the screening process determines the presence of antibodies due to the previous infection, then a second shot of the coronavirus vaccine may not be necessary.

Source:
https://www.nejm.org/doi/full/10.1056/NEJMc2101667?query=featured_home
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