Seizures during menstrual cycle linked to drug-resistant epi
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More frequent seizures during the menstrual cycle in women with genetic generalized epilepsy have been linked for the first time to drug-resistant epilepsy, when anti-seizure medications don't work, according to a Rutgers coauthored study that may help lead to tailored treatments. Women with a form of genetic generalized epilepsy called catamenial epilepsy—when seizure frequency increases during their menstrual cycle—were nearly four times more likely to have drug-resistant epilepsy than women who experience no changes in frequency, according to the study in the journal Neurology. This association was found in two independent samples.

In generalized epilepsy, seizures begin on both sides of the brain, while focal epilepsy seizures start in only one part of the brain. Anti-seizure drugs limit the spread of seizures in the brain and work for about two-thirds of people with epilepsy. Other options include surgery. The study included 589 patients with or without drug-resistant genetic generalized epilepsy at Columbia Comprehensive Epilepsy Center and 66 patients at Yale Comprehensive Epilepsy Center. The goal was to develop and validate a model for predicting generalized epilepsy that resists drug treatment. Such models may allow healthcare professionals to identify patients who may benefit from more aggressive or different kinds of treatment.

Source: https://n.neurology.org/content/early/2020/08/05/WNL.0000000000010597, Medicalxpress.com
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