Serotonin helps to promote liver regeneration following live
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For the first time, a research group from MedUni Vienna has proven that blood platelets and serotonin stored in them help in regeneration of liver but also play an important role in the recurrence of cancer following partial hepatectomy. The results have recently been published in the Journal of Hepatology.

A previous study showed that high intra-platelet serotonin levels lead to a better clinical outcome following liver resection, since the serotonin stored in the platelets presumably has beneficial effects on post-operative liver regeneration, which subsequently might reduce the occurrence of complications. Based on this study, it was hypothesised that influencing the serotonin level using drugs could boost liver regeneration and improve the outcome for patients following liver surgery.

The study included patients undergoing liver resection and serotonin levels in platelets were assessed before the operation. It has now been shown that patients with particularly low serotonin levels are more likely to suffer from complications and have a prolonged hospitalization after surgery than those with particularly high serotonin levels in their platelets.

However, if one looks at the recurrence rates for the resected tumours, the picture is very different: whereas patients with particularly high serotonin levels are more likely to experience early recurrence of cancer, those with very low serotonin levels are less likely to develop early tumor recurrence.

Serotonin was found to have this double-edged effect not only in primary liver tumours but also in metastases of colorectal cancer....

https://www.meduniwien.ac.at/web/en/about-us/news/detailseite/2017/news-im-oktober-2017/serotonin-helps-to-promote-liver-regeneration-following-liver-resection-for-liver-cancer-but-also-supports-early-tumour-regrowth/
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