Serum Irisin Useful As Early Biomarker For Predicting Gestat
This study was conducted among the pregnant women attending the Department of Endocrinology and Ob-Gy of MKCG Medical College for a period of one year with at least one risk factor for the development of gestational diabetes mellitus (GDM). Blood samples were collected for measurement of fasting plasma glucose, serum insulin, serum irisin, lipids (TC, LDL, HDL, TG), and HbA1c. Sixty-five patients were included in the study, out of which 20 (30.8%) patients developed GDM and the rest 45 patients had normal glucose tolerance (NGT). The first trimester mean serum irisin concentration was significantly lower in women who later developed GDM compared with women who had NGT (111.65 ± 25.43 ?g/L vs 185.89 ± 28.89 ?g/L). Serum irisin concentration was the best predictor with an optimal threshold value of 149 ?g/L, which had sensitivity, specificity, positive predictive value, and negative predictive value of 90%, 91.1%, 81.8%, 95.3%, respectively, for predicting GDM at 24-28 weeks of pregnancy.

The utility of serum irisin as an early biomarker to predict the development of GDM later in pregnancy in high-risk patients.