Severe hyperglycemia increases COVID-19 mortality risk for n
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
Severe hyperglycemia after hospital admission for COVID-19 significantly increased mortality odds among individuals not in the ICU, according to a study published in Diabetes Care.

Diabetes and hyperglycemia are important risk factors for poor outcomes in hospitalized patients with COVID-19. Researchers hypothesized that achieving glycemic control soon after admission, in both intensive care unit (ICU) and non-ICU settings, could affect outcomes in patients with COVID-19.

Researchers analyzed pooled data from the Glytec national database including 1,544 patients with COVID-19 from 91 hospitals in 12 states. Patients were stratified according to achieved mean glucose category in mg/dL during days 2–3 in non-ICU patients or on day 2 in ICU patients. They conducted a survival analysis to determine the association between glucose category and hospital mortality.

Results:
-- Overall, 18.1% (279/1,544) of patients died in the hospital.

-- In non-ICU patients, severe hyperglycemia (blood glucose [BG] >13.88 mmol/L [250 mg/dL]) on days 2–3 was independently associated with high mortality compared with patients with BG <7.77 mmol/L (140 mg/dL).

-- This relationship was not significant for admission glucose.

-- In patients admitted directly to the ICU, severe hyperglycemia on admission was associated with increased mortality.

-- This relationship was not significant on day 2. Hypoglycemia (BG <70 mg/dL) was also associated with increased mortality.

Conclusively, both hyperglycemia and hypoglycemia were associated with poor outcomes in patients with COVID-19. Admission glucose was a strong predictor of death among patients directly admitted to the ICU. Severe hyperglycemia after admission was a strong predictor of death among non-ICU patients.

Source: https://care.diabetesjournals.org/content/early/2020/12/08/dc20-1857
Like
Comment
Share