Sex Hormones, Chromosomes Might Play A Role In Better Covid
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Women face less severe complications and a lower risk of dying from Covid-19 than men due to the presence of hormones and chromosomes that contribute to a stronger immune response in female patients, according to a study.

It highlights how the sex differences in Covid-19 are linked to ACE2, an enzyme that acts as the receptor allowing SARS-CoV-2 virus to enter the body. ACE2 is also key in protecting against cardiovascular, lung and kidney diseases, the researchers said.

Because of their chromosomes, women have two copies of the ACE2 gene and men have only one copy, ACE2 is an X chromosome-linked gene, women have twice as many active genetic instructions to make ACE2, said senior study author Gavin Oudit, professor at the University of Alberta in Canada.

Another gene that is twice as strong in women due to this X-inactivation escape is called Toll-like receptor seven, a key part of the innate immune system. The stronger presence of Toll-like receptor seven in women explains why women's immune systems are stronger than men's and can tolerate virus infection better, including the common cold," said Oudit, adding "the man-cold phenomenon is real."

The study found that men face more severe illness and poorer outcomes around the world, even when women likely face more exposure to SARS-CoV-2 than men.

Source:
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00755.2020
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