Sex hormone deficiencies may be associated with rotator cuff
A retrospective analysis on 229,986 patients aged 18 to 64 years who underwent primary rotator cuff repair (RCR) for a rotator cuff tear from Jan. 1, 2008, to Dec. 31, 2017. The researchers also analyzed a control group of 229,986 patients who were matched for age, sex and year of RCR. According to the study, the researchers used data from the Veterans Genealogy Project database and multivariable logistic regression models to estimate relative risk for RCR for patients with and without sex hormone deficiency (SHD).

Overall, 27% of women patients in the RCR group were diagnosed with estrogen deficiency (ED) compared with 20% of women in the control group, while 7% of men patients were diagnosed with testosterone deficiency (TD) compared with 4% of men in the control group. Smith and colleagues found the odds of RCR for women patients with ED were 48% higher (OR = 1.48) than those without ED. Similarly, the odds of RCR for men with TD were 89% higher (OR = 1.89) than those without TD.

The study found that female patients with estrogen deficiency and male patients with testosterone deficiency have “significantly” higher odds of rotator cuff repair compared with patients without a sex hormone deficiency.