Sex differences in the diathetic effects of shift work schedules on circulating cytokine levels and pathological outcomes of ischemic stroke during middle age
Shift work is associated with increased risk for vascular disease, including stroke- and cardiovascular-related mortality. However, evidence from thesâ?¦
Shift work is associated with increased risk for vascular disease, including stroke- and cardiovascular-related mortality. Entrainment of circadian activity was stable in all animals maintained on a fixed light:dark 12:12 cycle but was severely disrupted during exposure to shifted LD cycles (12hr advance/5d). Following treatment, circadian entrainment in the shifted LD group was distinguished by increased daytime activity and decreased rhythm amplitude that persisted into middle-age. Circadian rhythm desynchronization in shifted LD males and females was accompanied by significant elevations in circulating levels of the inflammatory cytokine IL-17A and gut-derived inflammatory mediator lipopolysaccharide (LPS) during the post-treatment period. Middle-cerebral artery occlusion, 3 months after exposure to shifted LD cycles, resulted in greater post-stroke mortality in shifted LD females.
Source: https://www.sciencedirect.com/science/article/pii/S2451994422000050?via=ihub
Source: https://www.sciencedirect.com/science/article/pii/S2451994422000050?via=ihub
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