Short Meal-to-Bed Time is a Predominant Risk Factor of GERD
A recent study has reported for the first time that short meal-to-bed time was a predominant risk factor of gastroesophageal reflux disease (GERD) in pregnancy. This dieting habit eas significantly associated with reflux symptom frequency and reflux-related insomnia.

They aimed to assess the characteristics of GERD and the association between meal-to-bed time (MTBT) and GERD during pregnancy. It was published in the Journal of Clinical Gastroenterology.

A cross-sectional study was carried out on 400 pregnant women aged 18 years and older. GERD was defined as having troublesome heartburn and/or regurgitation at least once a week. Reflux-related insomnia was defined as having difficulties initiating or maintaining sleep through the night. MTBT was defined as "short" if it was ≤2 hours in more than two-thirds of days in a week.

There were 154 patients with GERD and 20 patients with reflux-related insomnia.

- In multivariate analysis, there were 3 factors significantly associated with GERD: third trimester, previous history of typical reflux symptoms, and short MTBT.

- The frequency of reflux symptoms progressively increased across subgroups of patients with no short MTBT, either daytime or nighttime short MTBT, and with both daytime and nighttime short MTBT.

- Nighttime MTBT was also a significant risk factor for reflux-related insomnia.

Conclusively, investigators reported that short MTBT was a predominant risk factor of GERD in pregnancy.