Short courses of steroids linked to severe adverse events- S
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (less than 14 days) is largely unknown.

This study aimed to examine the associations between steroid bursts and severe adverse events, specifically gastrointestinal (GI) bleeding, sepsis, and heart failure.

The participants were adults aged 20 to 64 years with continuous enrollment in the National Health Insurance program. Incidence rates of severe adverse events in steroid burst users and non–steroid users, as well as incidence rate ratios (IRRs) for severe adverse events within 5 to 30 and 31 to 90 days after initiation of steroid therapy.

Results:
-- Of 15859129 adult participants, 2623327 who received a single steroid burst were included. The most common indications were skin disorders and respiratory tract infections.
-- The incidence rates per 1000 person-years in steroid bursts were 27.1 for GI bleeding, 1.5 for sepsis, and 1.3 for heart failure.
-- Rates of GI bleeding, sepsis, and heart failure significantly increased within 5 to 30 days after steroid therapy initiation and attenuated during the subsequent 31 to 90 days.

Conclusively, Oral corticosteroid bursts are frequently prescribed in the general adult population. The highest rates of GI bleeding, sepsis, and heart failure occurred within the first month after initiation of steroid therapy.

Source: https://www.acpjournals.org/doi/10.7326/M20-0432
Dr. T●●●●z H●●●●●●i and 2 other likes this2 shares
Like
Comment
Share