Short-term Chemotherapy for patients with spinal tuberculosi
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The aim of this meta-analysis was to systematically evaluate the clinical efficacy and safety of short-course chemotherapy (less than 6?months) compared with the standard therapy (9–18?months) for patients with spinal tuberculosis (TB) undergoing surgery in Chinese population.

In this meta-analysis, data to determine the equivalence of short-course therapy (group A) and standard therapy (group B) for the drug therapy of TB in Chinese population was included. Weighted mean difference (WMD), odds risk (OR), and their 95% confidence interval (CI) were calculated.

Results:
--This meta-analysis included six trials published involving 851 patients (group A, 397; group B, 454) with spinal TB.

--Results showed there were no significant differences between group A and group B in clinical cure rate (OR = 0.61), change of erythrocyte sedimentation rate (ESR) (WMD = ??0.75) and bone graft fusion rate (OR = 2.32).

--Meanwhile, there were fewer side effects (OR = 0.37) in group A compared with group B.

Finally, the findings of this meta-analysis indicated that short-course chemotherapy may be similar to standard chemotherapy in terms of effectiveness and side effects for patients with spinal TB undergoing surgery in the Chinese population.

Source: https://josr-online.biomedcentral.com/articles/10.1186/s13018-021-02375-9
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