Significantly higher serum tumor marker levels in patients w
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The previous study showed that carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC–Ag), and ferritin are significantly higher in patients with oral potentially malignant disorders (OPMDs including oral leukoplakia, oral erythroleukoplakia, and oral verrucous hyperplasia) than in healthy controls (HCs). This study showed that three serum tumor marker levels were also significantly higher in OSF patients than in HCs.

The serum CEA, SCC-Ag, and ferritin levels in 41 OSF patients and 164?HCs were measured and compared. Patients with serum CEA level ≥3 ng/mL, SCC-Ag level ≥2 ng/mL, and ferritin level ≥250 ng/mL were scored as serum positive for CEA, SCC-Ag, and ferritin, respectively.


The result was;
--Investigators found significantly higher mean serum CEA, SCC-Ag, and ferritin levels in 41 OSF patients than in 164HCs.

--Moreover, 41 OSF patients had significantly higher serum positive rates of CEA, SCC-Ag, and ferritin than 164HCs.

--Of the 41 OSF patients, 26, 7, and 2 had serum positivities of one, two, or three tumor markers including CEA, SCC-Ag, and ferritin, respectively.

In particular, there are significantly higher mean serum CEA, SCC-Ag, and ferritin levels and significantly higher serum positive rates of CEA, SCC-Ag, and ferritin in OSF patients than in HCs. The serum CEA, SCC-Ag, and ferritin levels may be served as tumor markers for evaluation of the malignant potential of OSF lesions.

Journal of Dental Sciences
Source: https://doi.org/10.1016/j.jds.2021.02.009
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