Simplified Method for the Treatment of Band Keratopathy With
A Study was conducted to compare 3 methods for creating ethylenediaminetetraacetic acid (EDTA) solution using readily available Vacutainer tubes for the treatment of band keratopathy.

All 3 protocols used commercially available Vacutainer blood collection tubes coated with K2EDTA. An osmometer was used to measure and compare the concentration of EDTA created using 3 different protocols. The time required for preparation of the solution was measured and compared to evaluate its efficiency for everyday clinical use. In addition, volume of EDTA solution obtained was measured for method 1. The most promising protocol for clinical use was then used for treatment of a series of patients.

Results:
--Average osmolarity was 532, 285, and 422 for methods 1, 2, and 3, respectively.

--For the respective mixtures, average concentration was 65, 35, and 52 mg/mL, and average time to create solution was 189, 38, and 83 seconds.

--The most promising, method 3, was found to be safe and effective in removing calcium from the corneal stroma in a series of 5 patients with 6 eyes treated. It also yielded 25% more solution for clinical use than method 1.

In conclusion, the greatest balance for effective concentration of EDTA, preparation time, and ease of approach in comparison with pre-publication procedures 1 and 2, was Method 3, employing a single Vacutainer tube containing 18 mg K2-EDTA. There was also a larger final solution volume.

Source: https://journals.lww.com/corneajrnl/Fulltext/2021/10000/Simplified,_Readily_Available_Method_for_the.22.aspx
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