Sleep Irregularity and Risk of Cardiovascular Events: The Mu
The cardiovascular system exhibits strong circadian rhythms to maintain normal functioning. Irregular sleep schedules, characterized by high day-to-day variability in sleep duration or timing, represent possibly milder but much more common and chronic disruption of circadian rhythms in the general population than shift work.

This study aimed to prospectively examine the association between sleep regularity and risk of cardiovascular disease (CVD). In MESA (Multi-Ethnic Study of Atherosclerosis), 1,992 participants free of CVD completed 7-day wrist actigraphy for sleep assessment from 2010 to 2013 and were prospectively followed through 2016. The study assessed sleep regularity using the SD of actigraphy-measured sleep duration and sleep-onset timing across 7 days. Incident CVD included nonfatal and fatal cardiovascular events. A Cox proportional hazards model was used to estimate hazard ratios (HRs) for incident CVD according to SD of sleep duration and timing, adjusted for traditional CVD risk factors (including CVD biomarkers) and other sleep-related factors (including average sleep duration).

Results: During a median follow-up of 4.9 years, 111 participants developed CVD events. The multivariable-adjusted HRs for CVD across categories of sleep duration SD were 1.00 (reference) for ≤60 min, 1.09 for 61 to 90 min, 1.59 for 91 to 120 min, and 2.14 for >120 min. Similarly, compared with participants with a sleep timing SD ≤30 min, the HRs for CVD were 1.16 for 31 to 60 min, 1.52 for 61 to 90 min, and 2.11 for >90 min. Exclusion of current shift workers yielded similar results.

Conclusively, Higher day-to-day variations in sleep duration and timing are both associated with increased risk of CVD, independent of a wide range of factors including CVD risk factors, sleep duration, and sleep apnea. Because of the strong biological plausibility of our associations and previous research that implicated sleep variability with CVD risk factors, our results support considering inconsistent sleep patterns as a novel CVD risk factor and suggest the need to evaluate the role of healthy sleep practice interventions as a strategy for cardiovascular risk reduction.