Sleep disturbance linked to esophageal hypersensitivity
For patients with gastroesophageal reflux disease (GERD), sleep disturbance is associated with enhanced heartburn perception to capsaicin infusion, according to a study published online Nov. 29 in the Journal of Gastroenterology and Hepatology.
Chih-Hsun Yi, M.D., from the Hualien Tzu Chi Hospital in Taiwan, and colleagues examined whether sleep disturbance modulates esophageal sensitivity to capsaicin infusion in patients with GERD. Forty patients were enrolled and underwent sleep quality measurement by the Pittsburg Sleep Quality Index. The authors documented esophageal sensation to capsaicin infusion by measuring lag time to initial heartburn perception, heartburn intensity rating, and sensitivity score based on esophageal infusion of capsaicin-containing sauce....