Smoking, alcohol and coffee consumption and pregnancy loss
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The study shows the causal potential of the link of smoking but not moderate alcohol and coffee consumption with pregnancy loss.

The aim was to determine the associations of smoking and alcohol and coffee consumption with pregnancy loss.

A total of 60,565 cases with pregnancy loss and 130,687 noncases from UK Biobank and 3,312 cases with pregnancy loss and 64,578 noncases from FinnGen were included.

- Genetic predisposition to smoking initiation was associated with an increased risk of pregnancy loss.

- The combined odds ratio was 1.31 for one standard deviation increase in the prevalence of smoking initiation.

- There were no significant associations of genetically predicted consumption of alcohol or coffee with pregnancy loss.

This study on the basis of genetic data suggests the causal potential of the association of smoking but not moderate alcohol and coffee consumption with pregnancy loss.

Fertility and Sterility
Source: https://doi.org/10.1016/j.fertnstert.2021.05.103
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