Some of the principal treatments for osteoporosis could redu
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Some of the principal treatments for osteoporosis, denosumab, zoledronate and calcium, could have a protective effect against COVID-19 in patients who take them, specifically a 30 to 40% reduction in the rate of infection, according to the results of a joint study. The study, the first of its kind in the world, has been published the journal Aging.

The author explains that "there are indications to allow hypothesizing that certain drugs used to treat rheumatic diseases could interfere positively in the natural history of COVID-19, either by decreasing its incidence or by decreasing its progression to more serious cases". The study analysed data from more than 2,000 patients with osteoporosis, osteoarthritis and fibromyalgia and their relationship with COVID-19 infection.

In the case of some of the main treatments for osteoporosis, denosumab, zoledronate and calcium, data suggest a likely major reduction in the incidence of COVID-19 in patients who take them; specifically, between 30 and 40%, according to first author. "The study suggests that some of these treatments may protect patients against infection by COVID-19, although further studies still need to be conducted on more patients to prove it", he states.

In the case of denosumab, it targets the RANK/RANKL system involved in the balance of the skeletal system, but also the response by the immune system through the activation and differentiation of some of its cells. Its inhibition modifies the inflammatory response and acts on cytokines, which play a key role in infection by COVID-19. Zoledronate can also modulate the immune response and can stimulate its activity against SARS-CoV-2.

The results also indicate that another common treatment for these patients, the antidepressant duloxetine, may also have a positive effect in reducing the incidence of COVID-19. Conversely, a commonly used painkiller, pregabalin, seems to have a tendency to increase the incidence of the disease. In view of these findings, researchers suggest that "these antiosteoporotic drugs are safe and should continue to be administered to patients who take them. The promising results obtained with duloxetine are significant", while at the same time, "we conduct further studies to verify its possible beneficial effects on COVID-19" .

Source: https://www.aging-us.com/article/104117/text
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