Sporadic Creutzfeldt-Jacob Disease presenting with symptoms
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Creutzfeldt–Jacob disease (CJD), a common spongiform encephalopathy, is a fatal neurodegenerative disease. There are four subtypes: familial, sporadic, iatrogenic, and variant CJD. In sporadic CJD, clinical symptoms of myoclonic jerks, rapidly progressive dementia, a typical electroencephalography (EEG) pattern, cranial magnetic resonance imaging (MRI) data and 14-3-3 positivity have important diagnostic value. Besides the classical presentation, some neurodegenerative diseases presenting with rapidly progressive dementia such as Alzheimer’s disease, dementia with Lewy Bodies, Frontotemporal dementia, meningoencephalitis, progressive supranuclear palsy and corticobasal degeneration (CBD), can mimic CJD and make a challenge in differential diagnosis. We present a case of a 69-year-old female with asymmetrical dystonia and clumsiness of the left upper extremity, rapidly progressive cognitive decline and other CBS symptoms. The patient was finally diagnosed with CJD based on EEG findings, radiological findings, and cerebrospinal fluid (CSF) data. This aim of this case report is to draw attention to the unusual clinical presentation of this CJD case.

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