Statin treatment not associated with adverse neuropsychiatri
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Statin use did not appear associated with suicidality, anxiety disorders or seizures, according to results of a total-population cohort study published in The Lancet Psychiatry.

Using Swedish national registers, researchers linked data on dispensed statin prescriptions with data on unplanned (emergency) hospital visits or specialised outpatient care for four neuropsychiatric outcomes: suicidal behaviour (including deaths from suicide), depressive disorders, anxiety disorders, and seizures. They included all individuals in the registries who were dispensed statins and who were aged 15 years or older.

Findings:
-- The statin-users cohort comprised 1?149384 individuals, of whom 1?015?949 (88·4%) were aged 50 years or older, 625?616 (54·4%) were male, and 523?768 (45·6%) were female.

-- The study period consisted of 2053310 non-treatment periods and 2997545 treatment periods, and 957216 (83·3%) individuals had a medication status change (from on statins to off statins, or vice versa).

-- Suicide outcomes were found in 6372 (0·6%) individuals, depressive disorders in 23745 (2·1%), anxiety disorders in 30?100 (2·6%), and seizures in 28844 (2·5%).

-- There were no clear associations between periods of statin treatment and suicidal behaviour or deaths from suicide, anxiety disorders, or seizures.

-- Statins were associated with reduced hazards of depressive disorders, which remained after adjustment for concurrent antidepressant use.

-- Hazard ratios for depressive disorders were 0·61 with thiazide diuretic use and 0·84 with antihistamine use.

Conclusively, Statin use is not associated with suicidality, anxiety disorders, or seizures. Whether the observed association between statin use and reduced diagnoses of clinical depression is confounded by non-specific benefits related to being prescribed medication needs further research.

Source: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30311-4/fulltext
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