Strontium-doped bioactive glass and fluoride enhances hydrox
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Hydroxyapatite is the main mineral component of dental enamel. This crystallite has a needle-like structure and represents more than 90% of enamel mineral structure. Strontium-doped bioactive glass and fluoride have synergistic effects on hydroxyapatite crystallization by producing strontium-substituted-hydroxyapatite and strontium-substituted-fluorohydroxyapatite with enhanced bioactivity and reduced solubility which could be beneficial for caries management.

The study published by the Journal of Dentistry investigated the effects of a new strontium-doped bioactive glass and fluoride on hydroxyapatite crystallization and further its's beneficial effects on tooth enamel.

Researchers designed an in vitro experiment with calcium phosphate with different concentrations of strontium-doped bioactive glass (1 mg/ml or 5 mg/ml), and different concentrations of fluoride (0 ppm, 1 ppm, or 5 ppm). Tris-buffered saline served as a negative control. After incubation for 48 hours, the shape and organization of crystals were examined by transmission electron microscopy (TEM) and electron diffraction. The structure of the crystals was assessed by powder X-ray diffraction (P-XRD) and unit cell parameters were calculated. Characterization of the crystals was performed by Raman spectroscopy and Fourier Transform Infrared Spectroscopy (FTIR).

TEM and selected area electron diffraction revealed that the precipitates in all experimental groups were crystalline apatite. There was an interaction between strontium and fluoride with different concentrations on crystal thickness. P-XRD indicated the formation of strontium-substituted-fluorohydroxyapatite and strontium-substituted-hydroxyapatite in the groups with both bioactive glass and fluoride. Expansion or contraction of the crystal unit cells was influenced by the concentrations of strontium and fluoride. FTIR results confirmed the formation of apatite.

Conclusively, the results of this study suggested that strontium-doped bioactive glass and fluoride have synergistic effects on hydroxyapatite crystallization.

Source: https://doi.org/10.1016/j.jdent.2021.103581
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