Structural characterstics of Peripapillary hyperreflective o
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A Study was conducted to analyse the structural characteristics and perifoveal/peripapillary vasculature by OCT in children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and compare the results with those of normal subjects.

45 patients (84 eyes) under the age of 18 were tested with spectral domain-OCT and swept course-OCT for a fuzzy disc margin. Patients were classified into four classes based on the existence of PHOMS and the scale of the current PHOMS. No eyes with clear optic disc drusen (ODD) were included in the study. The foveal avascular zone (FAZ) and vessel densities from the macula and optic disc region were measured, and possible relationships between vessel density and structural parameters including peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (mGCIPL) thickness were investigated.

--Among 45 patients (eighty-four eyes), coexisting buried ODD were found only in eyes with PHOMS.

--The scleral canal diameter was significantly smaller in PHOMS positive eyes compared to control eyes.

--Vessel density measurements from the papillary, peripapillary and optic nerve head (ONH) regions in the large PHOMS group were significantly lower compared to the control group (papillary; P?=?0.014, peripapillary; P?=?0.001, ONH; P?=?0.046).

--FAZ area and macular vessel densities showed no difference compared to normal eyes in all three PHOMS groups.

--pRNFL and mGCIPL thickness did not differ among four groups and correlations were also not significant.

Conclusively, Children with PHOMS have smaller scleral canal and can entail buried ODD. Vessel densities in the optic disc region are slightly smaller in big PHOMS eyes than in normal eyes.