Study: Acid Suppression Does Not Improve Laryngomalacia Outc
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A Study was conducted to determine if the use of acid suppression and thickened feeds impacts laryngomalacia outcomes in infants, including supraglottoplasty risk, time to supraglottoplasty, and hospitalization risk.

A retrospective cohort study was performed to compare risk and time with supraglottoplasty and frequency and duration of hospitalizations for infants diagnosed with laryngomalacia. The primary outcomes were supraglottoplasty requirement, time to supraglottoplasty, and hospitalization risk. Multivariate analyses were performed to determine predictors of supraglottoplasty and hospitalization risk after adjusting for laryngomalacia severity and comorbidities in addition to propensity score adjustment.

Results:
--236 subjects with mean age 62.6±4 days were included in the analysis. 55% were treated with acid suppression.

--Subjects treated with acid suppression had higher risk of supraglottoplasty (HR 3.36), shorter time to supraglottoplasty, and increased respiratory hospitalization risk (RR 1.97), even after adjustment for covariates.

--Subjects receiving thickening had fewer respiratory hospitalization nights and longer time to supraglottoplasty, even after adjustment.

Finally, in contrast to untreated people, acid suppression did not diminish the frequency of supraglottoplasty and accompanying hospitalizations. However, thickened patients have reduced hospitalisation and a longer period of time for superglottoplastic thickening, which indicate that feed thickening may be a preference for acid repression.

Source: https://www.jpeds.com/article/S0022-3476(21)00633-8/fulltext?rss=yes
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