Study: Association with Recurrence of Macular Edema in Branc
A Study was conducted to identify factors predicting the recurrence of macular edema after the discontinuation of intravitreal antivascular endothelial growth factor injection in patients with branch retinal vein occlusion.

This retrospective study included only subjects who had discontinued injections at 3 months after the final bevacizumab injection due to fully resolved macular edema. 52 eyes meeting the criteria were included in the study and divided into two groups (recurrence and no recurrence).

--At the stopping point, the no recurrence group showed a thinner parafoveal inner retina, better best-corrected visual acuity, and lower incidence of ellipsoid zone disruption in multivariate logistic regression analysis.

--Similarly, parafoveal inner retinal thinning of more than 30 microm, when compared with the corresponding region of the fellow eye or the unaffected region of the affected eye, was significantly related to less recurrence of macular edema.

Finally, thinning of the parafoveal inner retina, as well as improved vision and intact outer retinal layers, are linked to a reduced risk of macular edema recurrence. These findings show that inner retinal atrophy caused by closure of a branch retinal vein may result in a decrease in oxygen demand in the afflicted retinal tissue and a decrease in vascular endothelial growth factor production.