Study: Childhood CCL18, CXCL10 and CXCL11 levels differentia
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Chemokines are important mediators in immune cell recruitment, contributing to allergy development. The aim was to investigate associations of circulating allergy-related chemokines with development of asthma and sensitisation cross-sectionally and longitudinally in a population-based cohort.

The chemokines CCL17, CCL22, CXCL10, CXCL11 and CCL18 were measured in plasma samples from children in the Manchester Asthma and Allergy Study. Samples were available from cord blood at birth (n=376), age 1 (n=195) and 8 years (n=334). Cross-sectional and longitudinal association analyses were performed in relation to asthma and allergic sensitisation, as well as allergic phenotype clusters previously derived using machine learning in the same study population.

--In children with asthma and/or allergic sensitisation, CCL18 levels were consistently elevated at ages 1 and/or 8 years.

--In a longitudinal model including information on asthma from 4 time-points (ages 5, 8, 11 and 16 years), a significant association was observed between increasing CCL18 levels at age 1 and a higher risk of asthma from early school age to adolescence (OR=2.9).

--Similar associations were observed in longitudinal models for allergic sensitisation.

--Asthma later in life was preceded by increased CXCL10 levels after birth, and decreased CXCL11 levels at birth.

Finally, the development of asthma and allergies awareness precedes higher levels of CCL18 throughout infancy. The CXCL10 and CXCL11 Th1 chemokines were likewise related to developing both results with difference time effects.